Endocrine Abstracts

Aims/Introduction: It is thought that adipocytokines contribute to the increased riskof vascular complications in type 2 diabetes (T2DM). However, some data indicate that adipocytokines may protect against cardiovascular disease. The net effects of adipocytokines on vascular pathology are complex and not completely understood. Although previous our cross-sectional studies showed that adipocytokines such as adiponectin, leptin, and TNF-alfa were associated with vascular complic...

Aims: To investigate the mechanism of α-lipoic acid (ALA) on preventing diabetes, we evaluated the effect of ALA on growth regulation and composition of skeletal muscle.Methods: OLETF and LETO rats, aged 24 weeks, were treated with or without ALA (100 mg/kg body weight/day in drinking water) and / or insulin (insulin glargine, 2 U/kg body weight/day; subcutaneous injection) for 8 weeks.Results: The treatment of ALA with or wit...